Non Insulin Dependent Diabetes Mellitus in Young – Overlap with Malnutrition Related Diabetes Mellitus
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چکیده
Diabetes in the tropics although not a homogenous entity, does have certain distinctive characteristics of its own. Genetic, nutritional dietary, and other environmental factors seem to be responsible for some of the differences noted between diabetes in tropical countries and diabetes in the West. Recent studies have highlighted the common factors which are shared by both noninsulin dependent diabetes in the young (NIDDY) and malnutrition related diabetes mellitus (MRDM) such as a low body mass index, lower age at onset, variable metabolic responses in response to changes in nutritional status and male predominance. Evidence in favour of familial aggregation with evidence of vertical transmission of disease from parent to offspring in fibrocalculous pancreatic diabetes (FCPD) has been put forward. The genetic predisposition to FCPD shares similarities with both IDDM and NIDDM. Prevalence of vascular complications, particularly those of microvascular origin are common in MRDM as in NIDDY and increases with duration of diabetes.
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تاریخ انتشار 2005